How Glucosamine is Used in Mountain Ice Pain Relief Gel
Glucosamine, one of the building blocks of cartilage, is a key ingredient in Mountain Ice Pain Relief Gel. Read on to learn how it can reduce joint inflammation and help you melt the pain away!
The Benefits of Glucosamine in Joint Health
Glucosamine is an amino sugar that's naturally present in cartilage, where it's required for the synthesis of proteins like aggrecan that form our connective tissue (tissue like joints, tendons, and ligaments that connects other forms of tissue, such as bone). High concentrations of aggrecan allow cartilage and the discs in our vertebrae to resist compression. Loss of aggrecan with age causes stiffness and joint deterioration. Its importance in forming these proteins means that glucosamine is necessary to maintain resistance and elasticity in joints, helping to repair and rebuild them.
Proteins like aggrecan are also responsible in part for retaining moisture in joints, which improves flexibility and reduces friction from movement, protecting cartilage and other connective tissue. Aggrecan in particular helps to bind hyaluronic acid, which retains moisture in connective tissue. This means that by synthesizing these proteins, glucosamine is ultimately responsible for lubricating your joints for better mobility and reduced wear.
Glucosamine and Osteoarthritis
Glucosamine has a number of mechanisms that may be of interest to those with osteoarthritis. In people with osteoarthritis, cells in the cartilage that moderate the breakdown of old cells and building of new ones can begin to activate incorrectly, accelerating cartilage breakdown while reducing the amount of new cells created. Glucosamine can help correct this imbalance by inhibiting the breakdown mechanism of these cells, called chondrocytes.
Glucosamine, like chondroitin sulfate, also has an impact on inflammation itself. In laboratory testing, both have been shown to inhibit the protein complex known as NF-κB (Nuclear Factor Kappa B), which controls many of the genes responsible for inflammation and regulating immune response. Excessive immune response is what creates the painful inflammation found in osteoarthritis, as well as the chronic inflammation in autoimmune and rheumatoid arthritis. NF-κB is active in numerous autoimmune diseases.
Glucosamine and Chondroitin Sulfate
Glucosamine works well with a number of other compounds that have similar effects in protecting and rebuilding connective tissue, including chondroitin sulfate. Both glucosamine and chondroitin improve the flexibility and elasticity of cartilage. They also both prevent its breakdown: chondroitin preventing friction by increasing the joints' water retention, which prevents the loss of joint-repairing glucosamine. And you'll get the full effect of both of these supplements working together in Mountain Ice Pain Relief Gel!